Harvard Professor David Sinclair discusses the potential to slow down and even reverse aging in a Health Theory episode. He explains the three levels of aging, lifestyle changes, drug treatments, and experimental procedures that may reverse aging. Sinclair emphasizes the importance of understanding the information theory of aging, the role of genes and epigenome, and the impact of cell pressure on aging. He recommends lifestyle changes such as regular fasting and cold exposure, and discusses the effects of metformin, exercise, and the use of NMN and resveratrol. Sinclair also shares his father’s story and the impact he hopes to have on the world.
Commentary:
David explains the information theory of aging [0:59]
David explains the difference between genes and epigenome [2:17]
David describes how cell pressure causes aging [5:20]
David explains what proteins are and how they work [6:40]
David recommends lifestyle changes to slow down or reverse aging [9:14]
David recommends emphasizing the system by regular [10:52] fasting
David explains why we don’t live as long as whales [15:01]
David describes resetting the circadian [16:16] rhythm
David explains how to know when someone is going to die [18:47]
David explains why people take metformin [20:03]
David shares his [24:18] exercise and metformin regimen
David supports cold [25:28] exposure
David explains the work he did to try and reset the aging [29:01] clock
David explains why you don’t want to turn the cellular clock back too [31:37] far
David describes the actual process of reversing aging in masses of cells [33:20]
David talks about certain outcomes with mice that look the opposite of aging [36:40]
David shares his father’s story about metformin and the use of NMN [38:10]
David Explains the Effects of Resveratrol [39:07]
David describes the types of tests he advocates [43:13]
David shares the impact he wants to have on the world [45:44]
Translated transcription (Google Translate)
To download a scheduled translation file with the SRT extension click here
What is really interesting and that is
Something that most scientists don’t even
To know about him still level three is the deepest
A layer of aging actually has DNA
A clock that tells our bodies how old we are
Can I take your blood and read
That and I could tell you about when
You’re going to die
Hi everyone hope you enjoyed it
Episode brought to you by our sponsors
At Peak Tea everyone is welcome to health
Today’s guest theory is David Sinclair
He is an esteemed professor of Harvard
Who makes some of the world’s most
Groundbreaking work on human longevity
It is read by Time magazine as one
The people who most influence
A planet and its new book The Lifespan
Revolutionary science on why we age
Why we don’t have to intentionally
Permanently change the way we think about
The inevitable of aging and maybe even
A death that’s exactly where I want
Start then this is my favorite topic
I want to live forever I don’t make bones
That’s what I know about right now.
I’m on a collision course with death
You have a really interesting theory
About what makes this era that if I
Not wrong you call the information
Theory of aging so what exactly is it
Information theory of aging and how
We take advantage of it so that we get older
We actually worked on it roughly
5,000 years or more and exactly the last
20 years we came with a set of
Hallmarks of aging are about eight
of them and I think many of your viewers
You’ll know there are telomeres
Attrition The ends of chromosomes get
Mitochondria are shorter than electrical packages
As we get energy
Older long laundry list
And most people in the fields have
We were told that we discovered aging
We have this list we put nice
Smooth pie chart and that’s it but what
I say that’s why all this does
Things happen is not enough just for
Mark what is happening that you need
Understand that there is a reason in the upstream of
All this and so in my book and in
Scientific articles we are currently publishing
For the scientific community to read as
Well, what we think is happening is
Our body loses vitality
Information as we age motivates
Many if not all those hallmarks
that we know exist so what in what way
is the epigenium involved in this
Do we lose the information that gives
People are a little quicker than about
The difference between genetics and I
Think they get and then the abigenum
And epigenetics and how it plays
Came out yes yes sure it’s not that
Complicated there are really only two main ones
Types of information in our bodies that we are
Get from our parents
The first is genetic that we all know about
DNA and the four letters Atcg is a
A long molecule in a cell and that is a string
of letters that are digital is like
The music that appears on these DVDs
Things we used to store movies
But there is another level of information
It is above the other in the cells which is the
The reader of the information that is called
The Avignome and it really is
Different because it is analog
Information in the same way that you write down
In men or tapes tapes are sucked
They were terrible in storage
Information but the problem is that we have
Analog version of information about
An epigenome that controls which genes
The DNA string turns on and off
And that’s why you’re considering it
Analog I don’t think I understand what it’s like
Actually works as I can imagine DNA
Sequences like a kind of repetition
Atcg code but what is analogous to
Afganium reading about each other to yours
The book is the first time I started
Imagine it in a different way well it is
It is very clear that if only you have
Four letters that it’s digital so we
Understand it but the epigenome is
The structure of how DNA is organized this way
DNA doesn’t just flutter like a
This string is basically packed around
Proteins that we call histones and it’s like
If you skip your pipe in the garden you
Loop it and then you can put
These loops to bigger buildings then
You get a chromosome that you can see
Any high school student could see below
microscope
It’s this chromatin structure like us
It’s called the epigenome and so when
When the hose is pulled out tightly
Characterized that stops the genes
that read so that genes are not in a state when they are
Compressed but also if the cell needs
Read specific genes and nerve cell
You have to read the genes of neurons
The liver cell needs to be read
Especially the genes of the liver cells
So they open those and now
Can I get access to and read the cell
It’s an analog system because it’s
Constantly changing it changes when you
Wake up what you eat so it’s really
The amount that DNA is not filled
And the place where it is not soaked
So you can read correctly and that’s it
What determines the functioning of the cell and
An identity that we know when we
We were born 26 billion cells each
These cells know what it is and what it is for
Should be 80 years after this and that
Offspring and for a long time what I am
The saying is that aging is caused by cells
Lose their packaging and then end up
Cells lose their identity disease and so
Following the cells check that they are transformed
Zombie-like
And then our essence is ours
Then our organs fail and we die but
Until recently we had no idea why this
Happened and therefore why does it happen
Well the packaging is really
An important part because similarly
The software runs the epigenome code
Determines which genes work intermittently
If you stress the system and by that I
i.e. biological stress and the greatest
Pressure that you can cause in a cell is
Break his chromosome because he goes
Die if it’s if it doesn’t fix or
Worse for the body you get so much growth
The cell should hunt the stop
Distribution of detention almost everything
Doing and then trying to fix the fracture
DNA but in this you have to do two
Things that first of all it should take
Proteins from somewhere else that are
Does a good job of maintaining the cell
Functions or verifies the cell
Correct functioning of the same proteins
Used by the cell to repair the DNA
It’s broken but so is what happens
At intermission it all opens up
Also because you remember then
Break DNA and it lasts that you can’t
Fix it you can’t glue it back
Unless you disassemble it plug it back
Together and then you have to repack
It’s this movement of proteins and
Unpacking and repackaging the DNA i
Believes that results in cells losing it
Original youth what we call garden
The pattern of expression of the state of genes
On and off and nerve cells like
They get older and lose their ability
Staying nerve cells and liver cells losing
Their identity as liver cells is fine
So are proteins like
You’re talking about them sounds
Little creatures I think of because of
On my background like powder like just
A type of inert molecule that is bright
Judging by the way you speak
I didn’t see them on them.
Animation beforehand as one likes
Formulate capable forms and they are actually
This move is so accurate
Well it’s actually that’s it
Super exciting when you get it
Proteins are not just stains or powders
The cell is actually a little bit
Small machines like a pac-man that goes
around and they can change the function
From other things they can pack the DNA
And what they do is create chemicals
Comments that would normally be required A
A billion years that will happen is what it is
The enzyme makes it accelerate the reactions
And so we have about 20,000 different
Types of enzymes in the body and they do
Different things but what we have
discovered in the last twenty years
There are certain types of enzymes
who help pack the DNA and help with
DNA repair These are the ones
Doing the ping pong game and without
The ones we’re with
In fact we will grow faster
On the other hand, what is really exciting
We found out that you can prepare them
More active to make sure the DNA is
Properly packed and the fix is
Very effective and there are ways you
Can do this exercise in the diet
Hungry they allow these enzymes
Control our bodies and make us healthier
They make these enzymes much more active
So instead of an undertaker doing it you’re
Exercise the diet Take them to take a
A molecule we’re working on and it’s going to go
Around and fix everything much more
effectively and leave you younger for
We think about why you use more
An analogy of a pac-man that makes me think about it
Is to eat something is what
that happens to be eating cells that have a
Entry level or is it more bob
The builder and it spins
Rip off a few things besides a few
Things together yes it’s more
Like Bob the builder but I think
At least a good example of enzymes
that we’re working on is called sirtuins that
Protect the body there are like
A pair of tiny little scissors that are chips
Cover chemicals known as acetals and
in this when they are disconnected the
Acetals of the same packaging proteins
DNA becomes more compact and it is called
Silencing genes and over time as we get
Adult and
Through this DNA damage process
Sirtuins get inactive which are
Distracted by DNA repair
Packaging of that DNA that tube
Spooling starts to be released and now genes
who have no business in the field
The mind has arisen and in part I believe
That’s why we have such diseases of
The brain dock is so interesting
Ok so the one I want to know Ma
Lifestyle perspective what we do
It speeds it up and then why
Can we do it from the point of view of lifestyle
Start slowing it down or flipping over
It’s good so I researched those
Enzymes sirtuins that we have seven in
I interrogated our bodies in them
About twenty-five years and what we have
It is known that they respond to
In the cellular environment there is a chemical
that they demand fuel think of them
Like a fuel called nad and there is another one
A molecule similar to the onset
The enzymes that make them balance
Faster and this is one of them called
Resveratrol We’ve Discovered For Years
Before red wine and together they
Actually doing really great things on these
Enzymes and causing them to maintain the body
Young people for at least 25 years
Studying mostly animals and even a little
Mushroom yeast cells and what we learned
From these studies, it is that these are
Mostly involved in responding to when
Organisms are under threat of survival
So how do you make the body feel?
It’s in danger of threat that’s how it is
Run a lot or at least go out
A breath that you know several times a week in your week
The body will say old man that we had nowhere
Away on one of those cats with sword-toothed teeth
Again need to build a body
I the other is to be hungry or
Twice a week or every day you
Know how to skip a meal or two and then yours
The body will activate those sirtuins that do
More than the same fuel in the ad for the enzymes
And we think that’s what’s part of it
Responsible for the health benefits of
These lifestyle choices are fine
But you’re talking about that me
which is really interesting is this idea
of what might be good for you when you
Young people may come back to bite you
Ass when you’re older yes so it’s like
The whole idea of hormosis that a
A bit bad is actually
outstanding
And this is exactly what you are describing
Now get out of the air to do other things
So when the information started flowing
that the only thing in each one
A known living organism that extends
Life expectancy is to eat less that you talk about
In your book it feels
You say do it for that reason
Just don’t put as much pressure as possible
System but now I hear you say no no no
What you actually want to do is click
The system won’t be that stress just me
Running Maria fuck I’m starving
It will not begin to stack and reverse
Problematic well actually if you move on
This snail will die so that it will be
Certain amounts of pressure you
Don’t want to do but what you want to do
Make the body fear a situation
The future but not enough to cause
Persistent damage or paper failure
DNA that will lead to diseases and
Ended up dying so you don’t want to
Exaggerate that you want to be a little bit
Swollen you want to be a little
Hungry
But of course, starvation nutrition is
Not going to make you live like that anymore
It’s a thin line and what we learned
From numerous studies on animals and increasing
The number of human clinical trials is
that you want to pulse, let the body
Recover not regularly that we used to do
Animals are hungry all their lives and that’s it
Worked but it actually works better if
You let them recover and I think it is
That’s the secret
So let’s really dive into it so I
Guessing you’re talking about where
Animals excluded something like 20 to
30 percent of their caloric intake for
Very long periods of time are prolonged
Their life is 30% so super
Interesting but you say that if
Their caloric intake over a long period of time
The time is approximately the same as for the animal
It’s just allowed to eat until it’s
I was satisfied that if it was done in a heartbeat
Hunger pattern and almost over
Feed they have the same
Benefits like the animal it has
Chronic and calorie deficiency
Well, let’s be clear that nobody knows
What is the perfect diet even when it is
Coming to fasting everything is basically based
About rodent studies so what can I tell you
About rodent studies I’m very much
Know that if you take a
Nibbles and reduces its calories by 25%
Throughout her life she will live longer
30% but it would be really miserable
Aggressive and this is true for us too
Well I tried calorie restriction
About a week I gave up that I was beautiful
Angry but what we discover
My colleagues found out that if you
It’s not just what you eat it’s when you
Eating is important and what was
Found that if as long as you have
The hunger period in the mouse so you
Can feed them every other day and then they
Can overeat themselves like they do
want and they do they eat about 90% of
Which mouse has free access to food
will eat but they have the same thing
Longevity benefit as this mouse
There was always hunger and if that’s true
What this means is that we can
Enjoy life as long as we have it
Hunger period once a day or maybe
Twice a week and I believe the only one
The reason we get older you know we can live for her
A thousand years otherwise the only one
The reason we age is that our repair systems
Be complacent You mentioned it
What benefits you when
You are young you will come back to bite you when
You’re old what we think it is
Very good repair systems when we are
Young so the idea is called
Antagonistic and in my opinion paleotrophy
That’s right and the one we’ve evolved to
Stay healthy and alive and fit to wear
For tea and then the forces of nature
Decrease in selection then from
In fact we have grown often
Children but we should not adhere to
Beyond that and body building
It will last a thousand years is
Pointless in knowing so much
Species only live as long as they need
Reproduce and then a little bit
More if you are a mouse that can die
In two years, they’re just building a body
It lasts for two years if you are a whale
that doesn’t have predators you can live in
How many centuries does it do more
sensation
Why does the whale live for a couple
A hundred years as I would say it is
Pretty sure to say surely in some
A spot in our past has become beautiful
Clear apex predator is not the stuff
Couldn’t get us out but I mean the
Great we will of course see how far we have come
Let’s not do that so why only
Living up to forty is that whales continue
Reproduce and be useful in this sense
It’s really interesting very few
People talk about it the reason is
that we weren’t on top of the edge of the food
Necklace until recently but in the world
Where we’re usually going to die from
From hunger or war
Men didn’t make it to 40 because of this
We were in the middle of the food chain
Only now we barely have
Chance of dying before 70 or 80 unless
Was unlucky you know give us another 5
A million years of evolution that we could
Developing a life expectancy of 200 years is what
Should happen if evolution continues a
A whale is at the top end about 30
A million years and they were allowed
To develop the long life expectancy that we are
Just like them we share most of them
Genes that are in warm blood they produce
Milk are aware that they are actually
us at sea so anyone who says yes
Reached our maximum limit don’t know
What are they talking about talked to me
On this idea of resetting
Circadian rhythm how it’s done
What is the mechanism and so it is clear
Going hungry every now and then physical activity is
going to help but I know you have a
A regime that I will read with love A
Regimen of drugs or precursors of things
that we can take what can be done to reset
This biological clock mmmmmmm there
They are different levels for resetting aging
There are three levels that we know of
The first one is quite easy to reset or perform
Manipulate these are the proteins that
Turning genes on and off very quickly we
They are called transcription factors and they
They actually call a garden and do a
Protein is what they do at this level
One that is easy to walk a little hungry
It will change the second level it’s a bit
Harder on the second level is not just
Change which genes are quickly transformed
Intermittent but actually mute genes
A lot of time and here is mine
Enzymes we work on or on
Incumbents they cut out the acetals
You disperse these packing proteins
Pipe and it becomes locked in
It’s that the gene is silenced because
Long time so you can practice
You can do a diet but also I think you
Need some help and also what
Gets really interesting and it’s
Something that most scientists don’t even
Still know
Is the third level the deepest layer of aging
There is actually a DNA clock that tells
Our bodies are how old we could
Take your blood and read it and I can
to tell you
About when you’re going to die what is
We can do it whatever you are looking for
We are looking for chemical groups that
will be added and missing the mark of our DNA
Because the long string and so you will get
Chemical changes in anticipation
Ways as you get older starting with
Perception so even in the womb even as
A child also as a teenager
Based on this clock that goes up
Linear and will you fit that line
It is very accurate that tells you yours
Biological age but how do you know when
Man will die it’s just
Based on straight lines is actuarial
Tables Oh average human person
Life expectancy is 86 and is what we mean or is
There you can see something specific
In my line that you will say you are going
For 68 sorry no it’s not specific
But on what is it machine based
Learning is based on thousands of people
Methylation code on the genome
And this comparison to their health and condition
The date of death oh it’s so interesting
So if you were to take my fees right
Now what would you be looking for exactly us
Would read Kampa’s Methylation
These are hydrogen and oxygen chemicals
Bound to DNA as a physical chemical
Peat and these accumulate as you get
Older ways are highly predictable
They are so predictable we could use them
The same clock for measuring the age of the dog
and a person’s age
Everything is based on methylation, right what
Causes of methylation Well there are two
Classes of these enzymes that add the
Methyl chemicals and deficiencies
It’s ok how do I take luggage of such boats
It misses it oh that’s what we are
Working on it now is the key level to it
Reset aging that we can do by some of them
The things I do in my life
yes you probably – these are not
Permanent changes you can not just do it
And expect it to take one treatment
And you continue to live another ten
Years are fine because level two is not similar
This constant is then fixed
One rank but rank three is really
Regularly you can reset yourself
Ten years then go back and then wait
Another ten years and possible to zero
Clock again if you know how to do
And we’re just starting to understand
Find out how
Ok so diet gymnastics on one cool level
It is at the level of two metformin that you take
Metformin is ok so I talked
About this program before but
Explain what metformin is and why it is
prescribed for diabetics and now why a
Allegedly rash of non-diabetic people
Taking it yes so there are three main ones
Pathways that regulate aging in animals
And we probably have in ourselves
Sirtuins that I talked about a lot
Today there is one called mTOR which
Reacts to some amino acids or how
Many amino acids are present in your body
Chase and protect the body
How few fewer amino acids it has access to
Ok ok so the third one is called ampk
And it’s the energy sensor when yours
The body has low energy levels that it will succeed
Allow the body to hunt and down
Protect myself from diseases but why am I
Worth mentioning that this is one
of the objectives as we call that of the drug
metformin metformin will trigger this
AMPK pathway and makes the body think
that it’s hungry often it’s not
Keep your blood sugar levels more
Stable why I was hungry on mobile
level or am I really experiencing hunger in
Stereo level ok but it also has
An interesting side effect is from a
A lot of people myself included that it’s a bit
Hard in the stomach so it also reduces
My appetite but what’s great about it
The metformin is that it has gone through millions
of people for several decades so that we know
Side effects affect the relative lengths
Really fast so metformin creates
On a cellular level, the feeling that I am
Hungry and you say it Ma
Perspective of the hormesis of a bit
Bad is like pressing on the system and
That’s why we think it works that this is it
Just doing it and for it to
Actually helps the body react in a certain way
Increase energy supply so one thing
It makes it undeniable
Increases the level that the number of
The mitochondria it basically creates
Extra mitochondria so your cells
Starting to be more efficient or more capable
Produce energy over time
Run but in short what it does is
It actually poisons part of the mitochondria
So it’s a bit of a ploy
And this leads to benefits
What a poisoned part
It is called complex so that there is
They are protons that are found in one part of the
Mitochondrial area in the crust
And you cell builds
Protons it becomes really acidic in it
Area but they cell wants
Let them go so what they do is they put them in
Small pores between the membranes so
They can leak from the high concentrations
Zone for the lowest concentration in the region
In the middle and when you pass through it
Its pores the pores around and that’s it
Rotating physically spinning it’s
Protein Chemical Energy Production
Called ATP so ATP is created
Without ATP we would have entered ten
Seconds yes ok it’s crazy
Interesting and you say sorry
Return to the poison that is the poison
Increase the causing levels
More actually a decrease in ATP in
Short-term so the cell says a man who doesn’t
There is enough chemical energy in ATP so
That’s what forces her to create more
Mitochondria are right so that’s it
Poisoning of this part is so amplified
The number of mitochondria is in response to
The only mild poison but there is
Two other important points where the cells are located
Our body also thinks they should
Be more sensitive to insulin Yes
which maintains our glucose and sugar levels
More stable ok yes that’s key because
This is what helps type two diabetes
Diabetics are recovering and you know prevents
The disease worsens Yes
The second is that it has just been
Discovered in humans that if you take
Metformin got a lot of it and used it
Can bump up the effects of exercise on
Build mitochondria what we think it is
Happens that it is that you do not want
There is always metformin in your system or
Your body will not have a chance to recover
From this mild poison I don’t go
Determine anything that I am not a doctor but
We think it’s better to take
Metformin on days when you are not
Exercise and recovery and heart rate
Again then you received a metformin exercise
Metformin comes out ok that I know you
Doesn’t list anything but a few
The days you take it and some days you
Not how often you exercise how
Often you are not
I actually spent a lot of my 30s and 40s
Not exercising at all is crazy right
Someone like me Hmm
But I would get better at it now that I’m
You know I’ve approached 50 now I’m 50
So I spend about 4 hours in the gym
Weekend with my brother Benny Benny
Like two hours a day and not four hours
Honest but not everything is fine exercise
I saw it was an hour with my coach Sean
which mainly does a combination of weights
And stretch some free weights
Machines and then it’s another hour on me
Owned with my son we make a treadmill
Some of them stretch more and actually
Just walking around and doing things is fun
For him and then we also then do some
A bit of yoga downstairs in the gym
A bit of relaxation but the most fun part
which I really like is at the end we do
Sauna Jacuzzi Cold Bath Sauna Jacuzzi
Bathroom cold for about an hour and I feel
Fantastic spoke to me often about this
In your book you enter a cold exposure
You said you passed the boss and that’s it
Sucks coming from Australia and you
Gather and now you wish you didn’t
Why exposure to cold and hot
Both are necessary what is the difference
Well there are several reasons why one is
A high-level view is all it is
Stresses that your body puts it in a state
of shock is good in the long run but a
A bit of perceived distress
A bit too hot a bit too much
Cold and especially a gradient between
These two and that’s why we jump from one
For the second point the next point is that I have
Look at the literature and at the beginning
When I was asked by my publisher to
Check it scientifically they said
You know what about this cryotherapy
What do you think and how many years
Before I had no idea it was real
Sounds like nonsense to me but I looked
Into it and there were two
One important thing is cryotherapy or
Cold exposure will establish what
We read brown fat mmm-hmm that we didn’t know
Brown fat is present in humans up to approximately
5 Years ago
Usually it is beyond your back in
Other reasons you can see with PET
Scanned but otherwise it pretty much looks
Just looks like fat but brown fat
Especially healthy because it has a
A lot of mitochondria and we think that too
Excretes few proteins that tell
The rest of the body to be healthy
In what way to be healthy we are not sure
Still
We’re not sure it’s interesting I mean I want
The answer to this question but it is
Definitely boosts your metabolism
Will burn energy if you look
Stay thin having little brown fat
Oh all good then my friend Ray Kronos
And I wrote about it and Andrew
Bremer and the NIH we call it the
Metabolic winter hypothesis
Basically it means you know
The lifestyle nowadays we are always warm
I wear this jacket that we sleep with
The covers on which we increase the heat
We are never exposed to cold unless
Force ourselves and we think it
It may be largely responsible if
No you know maybe maybe partially
Largely responsible for diabetes
We have what’s ok so if you
Cold at night you are going to burn a lot
More energy to stay hot Yes turn on
Your brown fat now it will retain
Thin people if we come together and we are
Eat the type of duck diets that we are
You will see in the supermarket that will be
Twice as bad for our bodies Yes, yes
It is hot that we do not lose energy and we are
Eating much more yes that’s it
The stuff is so interesting, so what
Your advice I’m all you stand for
Tell me no I’m going to make it so loving
How often do I want to do this
Is it everyday what it looks like
Well what I do is because I’m busy and I’m
No sauna or cold bath in the house
I am subject to myself to this material approximately
Time on Sunday and what I do is me
Dedicate about 15 minutes to 150 degrees
fahrenheit
Well it’s quite intense but you
Get used to it
Then we will enter the steam room you know
We sit there and chat it’s great
Temperatures are low in the steam room
Because the humidity is saturated with mmmm
Roofs dripping with hot water but that’s it
I don’t know if the steam helps me
Absolutely love the feeling of being inside
There and my skin starts to get healthier
Because it obviously cleans itself
And then the last thing I do is hot
Bath pretty hot water then
And then I go and dip under water mma
How many times in the water is less
From four degrees
Celsius so it’s so cold it’s
Takes your breath away yes yes but
It’s excellent
Interesting there was something else there
Level three that we should know about
Yes yes yes work we did recently
Only in the last year finds ways to do it
Pinch the cells and tissues of mice
At least to reset the watch we were on
Has been working for ten years as stated
Accelerates the clock we can drive it
Hand clock forward now we cut
The animal’s DNA let it heal inside
By doing so, we distract from these proteins
Where do they come from so that we are harassed
This cycle of survival is so much that we are
Disrupt the initiation of DNA and what
We got an old mouse for every bill
Based on the histology you look at
The tissues based on their physiology
They are gray they have contracted arthritis they
Have had heart disease even and when we look
In the methylation molecular clock
The watch had 50% older communities
If they were more like lumps everywhere
These methyl groups have been added to the
DNA is right right ok so we gave
Heart disease and Alzheimer’s or
Dementia gave them all these
Diseases but by measuring the clock what
That we did is give them aging
But that was the first step in it
Took ten years in the last year we were
Ask how you get your hands to walk
Backwards it is much harder but we
They were lucky to have the 2012 Nobel Prize
Won thanks to the ability to turn it around
The clock in the cells it was called was the prize
Awarded to Shinyaya Yamanaka in Japanese
Very smart guy and he found in
At least four genes that when you put in
Say adult skin cells if you give
You are your skin cells I could go back to
Lab and basically cloning you
I could take yourself to make a stem cell
Pool and I could raise you to innovate
Small liver or new small kidney
Everything is easy not easy but can be implemented
This can be done which tells us that it is
The four Yamanaka genes can reset age
If I can take someone who is like you
Who’s in their early forties and makes a new one
You are like we have done now for many species
Dogs cats is
Monkeys the animals that we can reset
One hundred percent clock and these animals
Actually normal life expectancy
Tells us that the instructions become
Young people still in a cell somewhere
Although there is a backup hard drive
Tells the epigenome the same coils how
Go back to being young again and get those
Methyl groups are back to being young
Not up here but there, but not
Remove them too far to have a stem cell
Or I’m actually going to make you a
Huge huge growth in the world yes, ok
One of the reasons why I become a tumor is because
The tumor is a cell unknown to it
Stop so what is it that you break
In that process makes it so
Not functioning yes yes in terms of the
Watch let’s start with this
Shinigami NACA has stunned the clock so far
Back it went back to zero back to
Midnight that we don’t want to do
Because cells lose their identity
And this is the last thing we want to do
We don’t want to get back to us because of
It is dangerous to have pluripotent
A stem cell in the wrong place in the body
Of course it will grow it will not stop
Growing but why not why it does it
Becoming a tumor Why it does not become a tumor
Heavy or lung as I would get the
A problem of liver development in me
Brain but I’m just saying like why
It becomes a tumor cell instead of a
Liver functions well so when
You go far enough away and lose it and lose it
Her identity she will simply honor herself
A mess without a cellular identity like this
There’s something else going on in this
Prevents him from understanding himself correctly
So in the lab if we take pluripotent
Stem cell and we want to prepare a liver
Cell or neuron nerve cell Yes we are
Give it a bunch of chemical signals
How we call the niche and when one of them
These cells land in the surrounding niche
These old cells they will use this stem
Cell rebuild tissues but imagine if we
Can reset the clock not to the end
Back to stem cell but only partial
Reset the clock so you can walk
Back to B20 again that’s what we are
Able to do in certain tissues in the mouse
Right now you’re doing it at Mass when he’s
Cell after DNA cell strand by DNA strand
Like how the hell do you get it
Take effect through an entire joint
Alone the whole body yes now
The way we do it is that we enjoy it
A virus called AAV and this virus
Will focus on specific tissues and provide
The genes for the most part fit in this
Tissues for example we treat aging
Eye in mice so we can take asleep
Mouse we transmit the AV virus to
Eye it’s a little little cock
It’s the same virus that one was used to
Correct genetic abnormalities in the eye
Currently FDA approved drugs so it’s
Not science fiction it’s out there
In the world at the moment we are letting him give
It’s for the old mice that we give them
Answer to this antibiotic called
doxycycline in the same order you can
Take if you have Lyme disease and it is
Activates these reprogramming factors
Do not use the four causes per kilometer of the operating system
They are called because one of them
Causes of the M cancer that we stop the M
We put the operating system and the K into the system I turn it on
Leave it on for a few weeks
Measure what happens to the eye and
These mice can see again as they were
Young people so we checked three different ones
Types of damaged eye damage
The first one we did was the Bard Mary so
A lab near us across the road is working on
Spinal rejuvenation and optics
A sadness that is crazy, yes, we know
Once you know a couple
Months old you are not going to regrow a
The spine It is one of the first parts of the
A body that ages and invents but jellyfish
Can regrow outstanding can re-grow arm we
You will lose this ability when we are very, very
Young people so we the question was if we would turn
The clock goes back a lot without protected gardens
Will these neurons be young enough
Return to the brain if injured
Them and that was the experiment they are
pinched the back of the optic nerve like this
that the nerves are damaged and they
I started dying back towards the brain
Because the mice have lost their vision
We’ve activated our reprogramming factors
Now you will see that the nerves are getting younger again
Turn the clock back and they grow backwards again
To the brain we can give ourselves
Healing ability that we only had when we were
There would be embryos and you start thinking
On what it can lead if we can
Do it safely
Of course sure is the important word
Imagine all over your body one day that you
Any cell in your body may be able to
Be renewed so that you cut
Yourself you break a bone
You lose your mind that you have
Dementia that you take in
doxycycline for a few weeks then
Stop turning it off again and you’re you
Heal if you turn it on at high levels
There is a laboratory in Spain that has shown
That you can get small growths in part
Animals in the kidney so we were very much
Be sure not only to blow up the cabin
These factors are permanently synchronized
From what we said lowered the levels
For very low levels and turn it off
When we don’t need it but we gave
Mice in this virus all over their bodies we
Inject into a vein and we will turn it on
We left it now in anticipation of mice
To die a year later are totally
Ok, so it seems to be safe but of
Of course there is much more work to be done
A scientist and I am a pharmaceutical developer I
Need to be very aware of the dangers
For sure please no one goes out to try it
At home until we know more
The AI is a good testing area because
It is protected and if there is
A problem is that you know it’s children
In the rest of the body it will not get too far
But all we know now is that it’s
Seems very safe at least on
Wow eye it’s crazy so that’s it
There is a component to improve
Improving human performance
Anything you can tease us well
We’ve actually published results in
Mice if you give them a nad amplifier
A molecule that will activate the pac-man
Enzymes called these mouse sirtuins
When they are old can now run 50 percent
Later, in fact, some of our old mice ran
So far the treadmill has stopped
Because mice aren’t supposed to run
More than 3 km we don’t have
I talked about every debt Tell me what Ned
What are the coefficients how do I
Plugin for it so there are several
I don’t support or sell the market
Anything by the way even if you see
Me as it’s not me so being told
There is one called NR which is
Stan that stands for My Oh Nicotine
Driver’s side which is very early
A precursor to falling in the body
There is an intermediate from the so-called
nmn not to be confused with M&s
Please don’t make it unhealthy
Then the cell turns nmn into nad and
You can take
All three of them in fact and / or each of them
These three raise NAD levels in
Animals and now we’re doing ourselves and
Many others do human research
We saw the NR and in my case MN
Does increase the energy levels of adults
People and young people are like up
to levels that we think you could rarely
Achieve even with a marathon
Running is crazy so just to bring
This house that people talk to me
Your father and the end of one
Experiments with N MN yes then my
Dad was in the same regime as
I’ve been resveratrol for more than a red decade
The wine molecule is passed from this and from
More than me because he did it
Had two types of borderline diabetes
diabetes and is also in n MN now and
He seems to be excellent now he is 80 years old
When he was in his 70s he was
Slowing down his own he started saying
The same things twice that you know typical
70 is great now he’s 80
He has a new lease on the life he started
A new career in Sydney is a traveler
of the world at the moment is traveling
Throughout America, he drives his elderly
A friend around his friend unfortunately
Ended up going to the last hospital
A few days so my father takes care of
of his friends that he sees on
decline
And he if any improves any
For a year I would love to hear more about it
resveratrol which is something I have
Completely deleted until I’ve started
Questioned you it looked red to him
A minute like it was real and then it’s
It seems to be completely dead and I know it
You’re caught kind of in the middle
Some of these things so where is it all
Forget like what pop culture thinks of it
It’s like what reality is in it yes
Resveratrol was proof of the concept
A molecule in its first 2003
A type that can mimic calories
Restriction to make mice healthy on
A high-fat Western diet and it was
Great proof of what we were
Trying to understand and this led to drugs
It goes into people who are really visible
Promise
I got involved with science and aa
Sogni corporate war in case of
Pfizer published a scientific paper
It basically said everything
David said he was wrong and then
It was a great title
Harvard scientists began companies
Wrong you know and then I take out
About a week in bed says fuck the
A world you know why I’m doing this why
Do I work so hard for the company if they
I don’t care but I work from bed
I thought let’s dig deep and see if
They write or if we are right and so
For three more years we really worked
It’s hard in my Harvard lab to test
If we were right then the question
Be with this undertaker who gets rid of the
The DNA works on it or it
Work on something else and that’s it
Scientists it is really important that
If it doesn’t work on all this
Drugs that we are trying to work on
Probably work incorrectly that way
We thought we’d cut back on a long story
What we found and posted on
Science magazine which is one of the leaders
You can do and I say it because it is
Verified science is that we showed this
Resveratrol has indeed been linked to pacman and
It’s responsible for that and we’re now
We have new information that we don’t have
Published but I will tell your audience
On this we created a mouse that is
Resistant to operation of the PAC-MAN
We can pinch the enzyme in only one
Amino acid in their protein approximately
A thousand blocking this traffic
Activation that usually chews
Here’s what if we add resveratrol to
A regular mouse that will make it our mutant
This mouse and that which is better either
The quick hug is the melting
It’s better that the quick was what we are
Think was responsible for health
Benefits and longevity so what
You show it by slowing it down
Cause real problems and thus if you
Have resveratrol there and get it
Touch really fast you did
Something is true positive and our mutant
A mouse should be resistant to
The benefits of resveratrol if we are right
But if Pfizer is right then resveratrol
Still supposed to provide benefits even
Although this enzyme works on some
Another way got it so that a mouse
The mutant mouse could not be expedited
Does not live longer when given to it
Resveratrol in a High-Fat Diet
so that there is the punctuation mark
Pho will arrive but interesting
The world has gone through a fine mm
I stayed to clean the pieces to the right
Yes, and when you say there is in the world
Moved on
Talking about people like me who just
Assumed it was rubbish and that
It’s not real and right ok so yes
said the only supplement you take
Is vitamin D so how do you manage
Resveratrol in this system is a drug
They should write it down
Well I take resveratrol that I have
We would call it a safe plugin and
It is commercially available if it is
It’s a legitimate seller and it’s 98
plus a pure percentage it looks like
Similar to what I take and park how
A lot you take I take a spoon into it
My yogurt is probably close to
Made every day every day yes ok
Resveratrol roughly grams you
takes n mm or is n mn or it’s just
Your dad we’re both fine and then
Metformin is right in these three things
Otherwise these are the main things that I
Think helpful and I would
Tracking my blood by chemistry so I
Did you say you took your own MRI
It’s true to notice that I like what things are
that we must examine to assume for a
Secondly I’m willing to go all the way
All crazy tests to know if what I am
Doing is working what would you do
Recommend
Well I avoid x-rays and CT scans unless
I have to
Surely true if your doctor tells you about it
Please don’t refuse it but otherwise
Don’t do it for fun don’t do it because
You are curious that these CT scans
Will break your DNA and when broken
The DNA of the mouse that its age increases
At 50% then who is right then avoid DNA breaks
As much as possible what I do is I take
Blood test of a company called
Tracker within the full discovery
I invested years ago and they are looking
About 30 parameters in your blood
Give you this supervised doctor feedback
So it’s legitimate and it’s based on
A lot of science and that at least gives
Get feedback on your body
What actually happens if you change
Your lifestyle or you take a supplement
Or even a new drug for that matter
You have to be a must
Tracking because you don’t, you don’t
Want to fly blind you don’t know if
You are doing harm or doing good
Do a blood test at least go to yours
Doctor and do a blood test for good
Sake
You can have your genome sequentially or
Do something that looks at the
Variants in your genome relatively
Small cost I think it’s $99 now that I’ve given
This kind of test for my whole family
As a Christmas gift and what we have
It became known that some of our members’ labs
Friends who are not other family members
Some versions predict longevity
Some do not have their mutations
A genome that’s a bit scary
The line that you can get your DNA
The age of methylation determined the truth
The so-called ruin clock some
People measure their telomere lengths
Have you performed a biopsy to do it or can you
Do it from a blood test in the blood is ok
It’s so interesting where you can
People learn better about you then
The main site is the book.com of life expectancy
There you can subscribe to the newsletter
and buy a copy of the book if you
Interested I strongly encourage it no
Thanks I’m also now on social media so I
I have a Twitter account I’m trying to talk to
About science about new findings
About things I’ve just learned
Things like that they might want
Log in so that my Twitter account is David
Sinclair and I have Instagram where I am
Send as much as you know you’re having fun
To do and not to do these kinds of things
And this is David Sinclair PhD fine
What impact do you want to have
About the good world it’s easy since I’m
I was four years old I wanted to understand
Find out why we died so quickly and you know
In my opinion I think it’s cruel to have
A good being who knows it will die
In such a short period of time it’s 80 years
Nothing that passes in the blink of an eye
Even a thousand years will pass in a
Blinking is only 20 times what I’ve lived
So I want to be able to leave an imprint
The planet I hope I’ve made it through the world
A little needle in the human trajectory
History I think we’ve come further than
Thought we were just
For life and that I still have some
I have to try and do what I am
Talking about fulfilled I definitely hope
So if you had to get people to do
One change that will be the biggest
Affect their health what will be a change
You’ve got the
Do so well after reading dozens
Thousands of papers and you did it for
Now thirty years and we’ve talked to people
And I know what’s at the forefront
The simplest thing you can do it
It has the biggest bang for the dollar is
A bit hungry don’t eat but that’s it
Not to say malnutrition don’t do it
Starve yourself literally having a lot
Teenage girls especially those who
Don’t eat enough so I’m not saying that
In general there should be a minimum
Nutrition but for those of us myself
Included who likes to eat those of us
They don’t mind a bit of dessert trying
Skip a meal I skip breakfast other than that
This yogurt I’m often too busy
Have a small lunch at the dinner I eat
Ordinary meal
I don’t adore myself because it will be
Stimulate all these protective pathways
to rebuild the body or at least
Keep it up until we have one
Things like level three reversal which
We’re working on it amazingly
Thank you so much for being here guys
Read the dive in the book if you are like me
And you want to live forever I say
You’re that guy at the very end of it
Exciting ball so check if you
I still wasn’t sure to sign up
Until the next time my friends will be legendary
Take care of a man who was amazing
Thank you to all
You all know how much you eat
A really important drink what you consume
affects you on a cellular level and
Dramatically affects your total
Health Tea Naturally Proven
Increase energy levels and provide immunity
System & Gut Health Support
What did Lisa go through can I tell
You are the one who focuses on your gut
Health is critical, so you can do it as well
Contribute to mental performance and may
Even help the longevity I had it
Peace with mental performance
Longevity Pitey makes some of the most
Easy and convenient tea to use on tea
Peak tea on the market is produced from
High quality organic leaves
ingredients from around the world and
Peak tea provides 12 times more
Antioxidants than any other tea
Also triple toxins irradiated liver
Pesticides Toxic metals and molds and mine
Staff here swear Pitty’s they love it
Things that the man behind the camera is
Really punched right now
Because he drinks so many of these things
Tea dishes for the peak are super convenient
They dissolve in hot or cold water and
They are perfect for travel or office
Or when you just need to grab something
On the go
And right now you can get 17 percent off
Their teas plus free shipping on the way
To achieve the impact on point T in life
Again this is the pinnacle of the edges point T point
Impact and spelled peak PI qee go
There is now to get this special discount
and check the description below or
Just click the link and get your record
Tea today Check it out guys enjoy being
Legendary keep thank you
A lot to watch and be a part of
This community if you haven’t been yet
You’re sure to subscribe
Weekly videos to build growth
The mindset cultivates gravel and unlocking
Your full potential
Leave A Comment