Did you know that people spend more money on healthcare in the last year of their lives than in their entire lives?
The American people spend $40,000 every second (forty thousand dollars per second) on the disease of aging. In fact, it is about treating people who suffer from the disease of aging, not about curing the disease, but only about trying to alleviate the suffering of the patients. 3.5 billion dollars are wasted every 24 hours on the disease of aging

(After a real video was broadcast to the audience about a person who ages in a few seconds)
Actually this is what happens to us in slow motion it’s just that we don’t think about it too much.
I’m Maria Entrigos and I work at a research foundation – we’re a non-profit organization in Mountain View, California

Subtitles:
hello everybody thank you so much for coming well that actually is what’s happening to us in slow motion it’s just that we don’t think about it too much I Marion dragus I work for sense Research Foundation we are a nonprofit organization in Mountain View California you probably heard of us I started helping over the gray do you know already stretch your hands yeah you’ve seen him before okay yeah so I I did over here many years ago and I contacted him started volunteering for him I all my life I thought about aging a lot since I was a little girl growing up in Argentina I don’t know why I was obsessed with it i just i would look at people who are old and feel bad and feel that it was something that we should do about it so when i moved to the US i I just I realized that already existed and we thought of the same things and instead of helping him and started helping him as a volunteer what really its aging what actually happens in our bodies why do we age so this is what over didn’t he he explains aging in seven different types of damaged cells Research Foundation I was a fully blown organization founded in 2009 we do intramural research with you extramural research so we have our own scientists and our own labs and we also fund research or other organizations and universities like you know back Institute Cambridge Stanford Harvard Rice University wake forest and the list goes on and also our work really it’s about health you know what causes most of this every day worldwide is related disease so all the diseases that we get that we will get if we live long enough like Alzheimer’s cancer cardiovascular disease Parkinson’s if we keep living the way we’re living now and the way medicine is right now we will get at least one of these diseases if not several of them and eventually we’re going to die of them so a hundred thousand deaths every day which is ninety percent of all deaths in industrialized world that’s what aging but we don’t we’re not only die of aging we suffer a lot we suffer a lot sometimes for a long time and everybody around the software Lord our families loved ones and we become a huge burden to society into economy in the health care system in the u.s. people spend more money on health in the last year of their life than in the whole life you know how much the u.s. spends on this you believe me if I said forty thousand a day and hour a minute a second forty thousand dollars per second spent on Aging on actually on treating people suffering from the disease of aging not not on on curing it and so that means that since i started my talk about 12 million dollars have been spent on this and the problem is that we’re not saving these people which is spending this money but these people are just getting worse and worse they can get a little bit better for a little while but eventually they will succumb to all these diseases we can do something about this way we have been really good at infectious diseases we will gotten better and better we will have vaccines and antibiotics but we haven’t done anything about the diseases that have to do with the generation the accumulation of damage which is what aging is aging is accumulation of damage at a cellular molecular level so our body basically produces his waste products that that just pile up in in ourselves between ourselves which is okay for a while but then it crosses a certain threshold and we start getting sick so we’re 20 we’re fine we’re already aging and we are accumulating damage but we don’t feel it and when we’re 40 you know we feel a little bit different I want to know though because I’m 29 but anyway that but when you’re 60 you start feeling it’s more and more and so on and then everything goes downhill we have gerontology and geriatrics taking care of this and all were doing is ameliorating the condition of the elderly but we’re not fixing the problem types of intervention gerontology and geriatrics gerontology basically postpones the processes and tries to slow down the processes but not by fixing them really and geriatrics looks more at the symptoms keeping people comfortable pain management and all that so what we want to do is we want to eradicate these diseases and we have this roadmap we are looking at a different approach which is a damage repair approach it’s a maintenance approach more of an engineering approach actually sense means strategies engineer for negligible senescence and I better remember sense sounds much simple but we thought of why not fix the damage instead of trying to modify the metabolism just take care of the damages like we do with you know any machines for example this dc-3 one of my favorite planes this is a brand-new airplane built in the 1930s it built to fly a certain altitude a certain speed carries an amount of people if you don’t maintain it it just ages and dies right but what about this this is 80 85 years after it does the same thing that it was designed to do back then because we maintained it and not only that we optimize that the propellers you know are better designer for fuel efficiency the GP it has gps that didn’t have before all the avionics are new the tires have better material stronger lighter that sit there these are the types of damage that or we talks about now I’m not a scientist and I’m not here to make you understand the science and I’m not the right person anyway so but this is um you know some of the main diseases that I mentioned because are the famous killers these types of damage are responsible for everything that happens when we age you know macular degeneration important see here in laws arthritis osteoporosis the list goes on and on the obsessive division of cells and you know so that start dividing dividing they don’t stop doing that in cells that don’t want to die is cancer mitochondria is the part of the cell that produces the energy and has its own DNA and the DNA starts mutating that’s big problem intracellular junk has to do with cardiovascular disease extracellular junk so it’s waste products that are accumulated inside of ourselves and outside of ourselves and get in the way extracellular cross-links were ourselves starts to stick to each other and that causes a stiffening over arteries and heart attacks strokes and wrinkles and wrinkles and wrinkles hey know if it was only wrinkles right but we get really sick as way everything’s happening inside and it’s affecting our organs and they start to fail all these seven processes are straight tie to aging this is what we need to tackle a solution we call a rejuvenation biotechnology we are creating an industry so we have to change our mindset the the way medicine is now doesn’t work so they have to look at this and what we are going is regenerative medicine applied specifically to this approach of repairing the damage that occurs in our bodies using a lot of these disciplines that you’ve heard of before tissue engineering stem cells by a nanotechnology gene therapy organ this is one example and I don’t have a lot of time someone to go quick but this is one example that has to do with the the junk in the cells the intracellular junk that causes the heart attacks and strokes so our body has been ability to break down accumulated metabolic waste products small amounts are okay as I was saying over 20 were fine we don’t know that this is happening but when we get more of the damage then crosses the threshold we get 60 70 80 cholesterol builds up and creates plaque and this plug leads to two heart attacks and strokes we have an approach of introducing an enzyme that will go in like like pac-man in the pac-man game and eat the plaque this is a enzyme that we took out of bacteria that we realized that this bacteria could actually do this what is what we’re not doing inside of our bodies with this plaque this bacteria can do it so we took her are already modified it and we’re going to introduce in our body so that can go in and get rid of this of this waste we have an animation here see if you guess who did the voiceover for it we need cholesterol all cells require into function and there’s little bit to ourselves via specialized particles in our blood but the sometimes these particles become trapped in the lining of our beloved essence white blood cells called macrophages we’re just stuck particles measures army processing in parts called lysosomes here the particles are broken down into their constituent parts for a recognition or disposal what’s the Assizes haven’t done their work the reclaimed cholesterol is returned to the blood but the problem is sasanka stroke becomes oxidized during its travels oxidized cholesterol so slowly process rather aggravates eventually over world of him preventing a Democrat even processing the realm of the class resorb he sink below the cells are called the bolsa cells and they attract of interactive ages but the new house suffer the same fate and this whole cells few might they mejor material plaques and become inflamed universe spilling of blood clots that trigger heart attacks strokes but what if we gave the macrophages of a new insight so think of process awesomeness cholesterol too then they would process suck particles without getting poisoned and loaded and returning a healthy function this is we progressively cleanse our teas apply it had already formed right it was a large Ames homes by the way he’s a big supporters anyway I have to finish i think i have 20 minutes but we have a type of intervention for each of these types of damage you can go on our website you have some literature and chairs come to me ask me questions we couldn’t do anything about aging before we can now things are changing really really fast as you know look at the stuff that happened only in a few years so really science fiction and science are meeting and remember we can have this we can have this is our choice and it’s going to happen eventually but it can happen faster if we change your minds mindset and start working so help us think you so much thank you I want to say that we have some books here some ending Aging books by over the gray that we’re giving for a donation so if you want to get one you can come to me yeah all right you